Your Textbooks Are Wrong, This Is What Cells Actually Look Like


I still remember the moment. That’s something
that I will never forget. The hair on my hands just stood up. It’s a microscopic universe
within each cell. This is an unprecedented view of the cellular world, where we can actually
see immune cells scooping up sugars in the ear of a zebrafish in real time. Focusing
only on the crawling immune cells, we’ve noticed two classes of them. One, it seems was not
hungry at all, but it was very active in terms of trying to figure out what the environment
is. But there was another one that was slouching around with a lot of food in its belly. We
can actually conceptualize, visualize, and analyze the contents of each of these cellular
compartments in this crawling immune cell as it’s scooping up its environment. That
is a level of detail no one’s ever seen before. We’re living in a new era of cell
biology, where microscopy advancements are giving biologists the opportunity to reveal
the hidden patterns of cells. What we expect to learn from here on out will transform our
understanding of human health and rewrite the textbooks on the fundamental unit of life. For centuries, microscopes have illuminated previously invisible worlds. We’ve learned
how cells divide and even discovered the existence of bacteria and microorganisms. These historical
breakthroughs are often found in your typical high school textbook. I fell in love with
the cell and wanting to understand the cell when I saw textbook images. I learned as I
started studying the cell, that those are vast simplifications of what those structures
actually do and what’s inside the cell. They don’t allow us to embrace the messiness and
complexity in the cell. At research organizations like the Allen Institute for Cell Science, biologists
are taking a more integrated view to better understand this complexity. So we at the
Institute are trying to think of all the structures of the cells in a holistic manner. If we don’t
understand which parts of the cell interact with which other ones we won’t ever be able
to understand the true mode of action of a drug, or perhaps where the side effects come
from. It’s that integrated knowledge of how when you pull here, you move there, that allows
us to understand the cell or the tissue or the organism properly. And if you don’t do
that you’re going to miss really important things. In order to see the patterns that
are actually happening in the cell in space and time, we have to be able to image the
cell well in space and time. New microscopy is what’s allowing us to image a cell in three
dimensions, in their native context without killing and hurting the cells, which is just absolutely needed for us to just study the cell as it is. But
seeing biological processes inside living samples without harming them is easier said
than done. One of the ways scientists image these dynamics is with fluorescence microscopy.
However, harsh light from this technique can cause phototoxicity, meaning the cell can
get sick during the imaging session. Lattice light-sheet microscopy was invented a few
years ago to correct for that challenge. So it’s a non-diffracting beam, meaning that
as the beam is traversing through the sample, it’s not converging or diverging. We put
several of these at very specific positions such that you interfere every beam with itself
and then create a very thin sheet of light. This fine sheet of light repeatedly sweeps
over a sample in order to avoid the damage that’s typically associated with other microscopy
techniques. The result builds a high resolution 3D movie depicting relatively undisturbed
living cells functioning over time. But tissues and other biological structures surrounding
cells tend to scramble the light from the microscope, resulting in blurriness. To compensate
for this, the same team behind the lattice light-sheet microscope borrowed a trick astronomers
use to get clear views of distant stars – adaptive optics. Just like how astronomers use lasers
as “guide stars” to course correct blurriness in telescopes, the process for looking at
the infinitesimally small world of cells through thick tissues and in living samples works
in the same way. Using a laser guide, aberrations that distort the light’s path are revealed
and corrected by the microscope. There’s several examples where we’ve worked with some
of the biologists, and showed them a few of our samples. Their reactions have typically
been, “Even though I’ve been studying this for a decade, it’s as if I’m looking at this
for the first time.” And that is always inspiring. Even just talking about this is giving me
goosebumps. With such promising feedback from biologists, Gokul and his
team of instrumentation scientists and computational experts are taking that technology one step
further in a newly created imaging center in Berkeley. This is unlike any microscope
you may have seen in high school. Its purpose is to shed light on molecular mechanisms that
are either poorly understood or not understood at all. MOSAIC is the Swiss army knife microscope,
as we have called it during development. And the reason we’ve called it the Swiss army
knife is because when we were trying to miniaturize the adaptive optics with lattice light sheet,
we realized that all of the components that go into building that microscope can be repurposed
to build a completely different microscope. MOSAIC combines about seven to 10 different
imaging modalities into one microscope. You can reconfigure or transform the microscope
from one mode into another mode. Such that you can interrogate your sample using different modalities. We’ve imaged everything from live
imaging, also everything that’s dead as well. Cells didn’t evolve in isolation. Cells didn’t
evolve on a cover slip. The goal of this whole project was to see, hey, can we create a tool
that will allow biologists to be able to look at their particular processes in a more physiological,
more natural environment. For you to have an effect in medicine and other fields, you need to understand to be able to perturb, mitigate and or intervene, right?  And that’s
basically what this is doing. This instrument is going to be laying the groundwork in order to help understand how a virus enters a cell. For instance, if
you can understand the mechanism by which it’s
fusing to the plasma membrane and then injecting its contents into the cell, you now have the
ability to intervene. The team behind MOSAIC has already built one instrument, and is in
the process of bringing a second one online. The next step will be opening up the instrument
to biologists. Because the thing is we can only get so far by ourselves. The goal is
to make sure folks that have the ability to have the impact, we want to make sure we break
the barriers down. Whether it’s access to instrument time, whether it’s access to computational
resources or working with the computational biologists. With tools like these soon coming
online, biologists like Susanne are excited about the next decade of cell biology. We
basically have a little alien world that none of us can wrap our minds around, and it’s
all of these technologies that are allowing us to start to do that more intuitively. Imagine
a world where you could look at a cell and you know what it’s doing, what it has done
and what it will do. That means that you could collect a pathological specimen, and without
too much perturbation or staining collect a whole bunch of information and features
just from the image, that let a pathologist know something about the prognosis of the
disease and the mechanism of why that’s the case. There will of course be more and more
innovation. That’s always how it works, but this set of innovation is going to get translated
into useful results for everyone. There’s literally trillions of inanimate molecules
inside of cells that work together somehow to create life. That’s basically what thousands
of scientists around the world are trying to understand is how life works. We want
to watch the dynamics, the interplay between these molecules in order to really understand
the complexity, understand the beauty of what is happening within the cells. Biology is
probably one of the last human forefronts. It’s the age of exploration again, but instead
of looking out at the galaxies, we’re looking at the galaxies inside of the cells.

100 Comments

  1. Hi Seekers, thanks for watching! Want more on the ever-changing world of microscopy? Check out this Elements on the world's first MRI of a single atom: https://youtu.be/pjiD0FrUNN8

  2. Rajesh kootrapalli ended with microbiology instead physics

  3. 5:37 Looks a lot like Cymatic geometry/formations

  4. Scientists can’t explain what happened before the big bang, and religious people can’t explain what happened before God. They are the same and both believe that something somehow came from nothing. The Big Bang actually happening and God existing are both equally possible, neither have been 100% proven or disproven.

  5. so i guess all those microscopes were lying huh

  6. ex-cell-ent video

  7. Don't waste your time. This video is 97% this guy talking, and barely any actually cells graphics. Gotta love these clickbait titles.

  8. The human body is insane …

  9. So, let's go back to the likes of Antoine Bechamp and Royal Raymond Rife, etc. and see that they were on the right path.

  10. Check out Dennis eggleston on YouTube.

  11. "…the galaxies inside of the cells." Maybe we're infinitely small, living inside of a cell (our known universe). Billions of years for us might be a few days in another timeline for the cell. Who the hell knows! I'm just glad we're getting closer to finding out.

  12. This is beautiful, genius, and really inspiring.

  13. So you're also was inspired by Osmosis Jones and Hataruku Saibou?

  14. Goddamn there's some smart people in this world

  15. :O

  16. This is what technology does for us. This aims for accuracy and convenience in getting the image of our cells and tissues.. as well as knowing their activities/processess in detail

  17. This video is cool, shows how much we are progressing technologically.
    Our text books are also outdated on the make up of an atom. To me that’s a little bit more interesting than this because the cell involves or known space-time world. Where as the atom consists of mostly empty space which gets into the world of the quantum, the unknown.
    In the future future both will go hand in hand very well together.

  18. Is his real name Gokul? Wtf cool parents he must have

  19. We’re living in a new era of biology? Lol, we’re living in the current era of technology

  20. Also thumbs down!

  21. Don’t need a lazy video to show what a cell looks like. Look at one through a microscope. Science is right.

  22. Put the Wim Hof and his tribe of Ice under this microscope!

  23. He looks like Bruce banner in an indian essence 🤔

  24. It's an amazing tech and outcome of years research but I still give you a dislike just because of your title. This title caught my eye for sure but I feel being lied after I finish this video. Maybe next time you might consider more seriously about how you title your video. I can't tell you how much I hate the way of the media titling their products nowadays.

  25. What if… each cell is an individual universe
    and we're living on a universe from another organism?

  26. Really really oh my. Now what to do

  27. I don't understand a thing but I know that the guy says he world works with cells

  28. so basically they're making our science lessons harder

  29. Give your life to Jesus Christ. Believe and pray: God, I know that I'm a sinner and unless you save me I'll be lost forever. I believe that Jesus Christ is the Son of God, died on the cross for my sins and arose on the 3rd day. I accept Jesus Christ as my Lord and Savior. In the name of Jesus, Amen.

  30. This is amazing and all, but has anyone esle saw Pyramid Head on the thumbnail?

  31. looks like the intro to metroid prime

  32. Can i get a full season on TLC this shyte is interesting

  33. Next i wanna see an atom turn into a cell

  34. good

  35. Clickbait

  36. we are just cells of a human

  37. I liked this video before it even began.

  38. So they're still artistic renderings….? Yeah okay cgi… We still don't know. Whole Lotta complexity for simple solutions. Don't want to get cancer?? Stop eating trash. Simple. Don't want to be medicated for the rest of your life? Stop eating trash! Really it's what we put into our bodies that's harmful, get back to the natural laws… We don't need to 'understand' anything. Eat fruit, eat salad and vegetables. Preferably raw. Everything will heal post detoxification. "cancer", obesity, high blood pressure, ED, etc etc. Since when has the mainstream medical/scientific establishment created anything that actually heals us? Never… 😷 Healing comes from within. 💛

  39. Mitochondria is the power house of the cell

  40. this complexity in the cells makeup only proves that a god of great powers can assemble such a piece of work, will they not understand?

  41. This is basically scanning and analyzing a cell in its 3D form.

  42. Is the nature of our existence like an internet of cell sentience through tissue and chemical messengers, a direct model of the concept of super consciousness in a microcosm, or something else? Does the nature of this relationship (million of tiny living entities forming a sentient living human) suggest any correlation to the primitive superstitious assumptions ancestral humans could only conceptualize in terms of deities as people come together to 'understand' one or more metaphoric beings into perceived form or otherwise interpret reality in such a way as to echo the existence of an idea that may actually just be the nature of themselves and the realm around themselves projected outward as our consciousness exists through a network of synapses, axons, dendrites, the remaining biological structures comprising neurons? The way two ideas are the same doesn't account for the way those same two ideas are different so metaphors will never fully accurately describe a phenomenon but If I can only exist healthily based on the healthy function of a million tiny organisms living, working for a specific purpose, and then not existing as they're purposed to do in nature does this bear any resemblance to what I'm meant to do as a human being or what humans are meant to do as societies? Does the life of a cell implicate any wisdom for human life? Does the nature of cells implicate anything about the nature of larger organisms?

  43. So, cellas are not round egg yolks with a little ping pong ball inside anymore?

  44. Subhan Allah

  45. When you look at life through the eyes God gave you will see that man is nothing more than dust of the earth,*¤*!

  46. It always comes back to looking within. Cellf-recognition.

  47. Just wait until the "Perfect Lens", which utilizes metamaterials, comes online… nearly infinite magnification for microscopes and telescopes.

  48. Youtube > Textbooks

  49. -What is your name? – Upadhyayula Gokul.

  50. We truly live in an amazing time.

  51. Looks like a sponge- kind of like a loofah lol

  52. GOKUL SEE You tube Mud Fossil University has discovered DNA of giants and humans from millions of years ago in MUD FOSSILS . Also has Discovered what causes AUTISM at cellular level . Berkeley ignores the lab samples Roger has sent them. GOKUL REACH OUT CONTACT ROGER AT MUD FOSSIL UNIVERSITY PLEASE!!

  53. Ok boomer

  54. What happens when you put a cell infront of a mirror

  55. They simplified complex contexts for individuals to find it less difficult to comprehend.

  56. Wow

  57. The Allen Institute for cell science team are amaziballs!!.
    Phenomenal research. Thank you so much

  58. "God" needed to find out who he is/was/will be..

  59. Why so many people disliked this vid is beyond me… katy perry's fans i suppose…

  60. I remember around 4 years ago, I found video about animation of world cells. Now, Youtube suggest a video about new advance in microscope, MOSAIC. Great suggestion and improvement, Youtube. Way to go, Seeker! I use to be your fan when I am still elementary age.

  61. Our bodies are like self contained universes. And we walk around oblivious about what is happening in our own bodies and all the little cells working to keep us alive and do the functions we require.
    All those immune cells being the soldiers guarding our bodies. The other cells bring nutrients and cleaning up waste.
    Not to forget the billions of bacteria living in symbiosis with us, mostly in the gut. In fact I heard that something like 80% of our actual immune system are these bacteria aiding us.
    We actually would basically die and not function properly without these bacteria.. It's fascinating.

    Science bitch! – Breaking bad.

  62. from Cells to the stars

  63. There u have it

  64. Was easy to draw cells, nerves and especially neurons (was the easiest for me to draw look so similar to a baby root of a tree like bean sprouts or something lol) bk in our school days then lol😁😎😁

  65. Let's all just agree to call this dude Goku from now on, yeah?

  66. "Look a contradiction eating another".

  67. "Your Textbooks Are *Outdated*, This Is What Cells Actually Look Like"

  68. Where can I go to see the actual footage from this thing?

  69. anny place we can get those scans ?

  70. Disappointed. Thought it would be like how the organelles were different inside or how their shapes were actually triangles smh

  71. SUP BRO HAPPY SUNDAY BRO SO HOW YOU DOING TODAY BRO

  72. Textbooks shows a diagram not an actual cell.

  73. Funny thing is i already knew this as above so below what is inside is also outside

  74. This kind of evidence only demonstrates how powerful and intelligent Jesus Christ God is. For the stubborn atheist is left to attribute everything to chaos and billions of years.
    "He [Christ] is the image of the invisible God, the firstborn of all creation. For by him all things were created, in heaven and earth, visible and invisible, whether thrones or dominions or rulers or authorities — all things were created through him and for him. And he is before all things, and in him all things hold together." (Col 1.15-17)

  75. Mudfossil University sent me here, and I'm just so happy to see the title of the video, this is some amazing stuff, the truth is getting out slowly but surely, but it's getting out there, keep up the good work, and don't ever be afraid to tell the truth

  76. So hippies were right all along. Duuuude, there is a universe in all of us.
    Tiny people are living on my cells and im trolling them with global warming every time i take a bath.

  77. Idk I hear red flags throughout the whole thing.. it's like there is an umbrella co. and next thing you know we're capable on enhancing our cells and you know what? Do they want a zombie apocalypse? Because that's how you get zombies.

  78. Looks at the picture
    Pyramid head?

  79. This is all gonna be used on us for control eventually.

  80. This is incredible! Amazing work everyone!! I can't wait til we can use this on humans for ultimate imaging

  81. If you can look at a cell and know what it's doing, what it's done, and what it's gonna do then you can do the same with humans. As above so below

  82. Is that real!!!! What about what I studied !!

  83. SUBHANALLAH

  84. Cells dont look like that they look like waifus, husbandos, lolis, and a tokyo ghoul reject

  85. ❤️😍😍

  86. Respect+
    This Sure does needs Attention of Media.

  87. All I can say is WOW!

  88. And what part of Tijuana is this research taking place?

  89. My civil engineering books showed only math formulas. Buildings are not made of formulas so they must be wrong too.

  90. Wow! My mind just exploded!

  91. Woah

  92. Textbooks are drawn to simplify…no logical person thinks that's how they are

  93. Amazing…I'm in complete awe. Absolute genius.

  94. Who else wants one of these at their house?

  95. Truly Amazing! I love this! Keep it up! Technology is always so interesting and amazing!!

  96. Wypipo tryna grow melanins:

  97. The pharmaceutical companies and current "medical" industry do NOT want the cures to diseases. They just want to sell drugs which only treat the symptom and then cause more diseases. That way they can profit and continue to profit until the victim dies. If you figure out how to cure everything then they can't make money. That's why they will do whatever they can to STOP this kind of research.

  98. The text books and regular microscopes are just a 2D view.

  99. Maybe your dumb american cancer text books

  100. Ya whatever eat your fruits veggies legumes you dont need any of these shit machines contributing to global warming & all the horrors born of it

Leave a Reply

Your email address will not be published. Required fields are marked *